Move oven rack to middle position and preheat to 425 degrees F. Lightly spray a 9x13-inch pan with nonstick cooking spray, and set aside.
Salt the cooking water, and cook the elbow pasta as per package directions to al dente, DO NOT overcook the pasta. Drain the pasta and return it to the pot.
In a large saucepan over medium heat melt the butter. Once the butter has melted, whisk in the flour and stir constantly until the mixture darkens slightly in color, about 2-3 minutes. Slowly whisk in the milk until combined. Whisk in the onion powder, mustard powder, garlic powder, salt and pepper, and cook, stirring constantly, until thickened. It will take about 3-5 minutes for the mixture to thicken.
Turn the heat off and whisk in the cheddar and Parmesan cheese until the cheese has completely melted.
Pour the cheese sauce over the cooked macaroni and stir to combine. Then, pour the macaroni into the prepared pan and smooth into an even layer.
MAKE BREADCRUMB TOPPING:
In a small bowl stir together the bread crumbs, butter, cheddar, salt, and pepper until the breadcrumbs are evenly coated.
Sprinkle breadcrumbs over the top of the macaroni.
Bake for 20-22 minutes, or until the edges of the casserole are bubbly and the breadcrumb topping has turned golden. Move the pan to a wire rack and cool for 15 minutes before serving.